Precision HLA typing from next-generation sequencing data.

Precision HLA typing from next-generation sequencing data using OptiType.

Table of Contents

Introduction Quick Start

With Docker With Singularity

Documentation Pipeline DAG

Input fastq Input bam

Credits

Introduction

OptiType is a HLA genotyping algorithm based on integer linear programming. Reads of whole exome/genome/transcriptome sequencing data are mapped against a reference of known MHC class I alleles. To produce accurate 4-digit HLA genotyping predictions, all major and minor HLA-I loci are ...

nf-core/deepvariant

Deep Variant as a Nextflow pipeline

A Nextflow pipeline for running the Google DeepVariant variant caller.

What is DeepVariant and why in Nextflow?

The Google Brain Team in December 2017 released a Variant Caller based on DeepLearning: DeepVariant.

In practice, DeepVariant first builds images based on the BAM file, then it uses a DeepLearning image recognition approach to obtain the variants and eventually it converts the output of the prediction in the standard VCF format. ...