Galaxy COVID-19
OverviewInitial analysis of COVID-19 data using Galaxy, BioConda and public research infrastructures
Space: This Team is not associated with a Space
SEEK ID: https://dev.workflowhub.eu/projects/8
Public web page: https://covid19.galaxyproject.org
Organisms: No Organisms specified
WorkflowHub PALs: No PALs for this Team
Team created: 25th Mar 2020
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Evolutionary Analysis
Live Resources
usegalaxy.org usegalaxy.eu usegalaxy.org.au usegalaxy.be
What's the point?
Wu et al. showed recombination between COVID-19 and bat coronaviruses located within the S-gene. We want to confirm this observation and provide a publicly accessible workflow for recombination detection.
In previous coronavirus outbreaks (SARS), retrospective analyses determined that adaptive substitutions might have occurred in the S-protein Zhang et al., e.g., related to ACE2 receptor ...
DownloadAnalysis of S-protein polymorphism
Live Resources
usegalaxy.org usegalaxy.eu usegalaxy.org.au usegalaxy.be
What's the point?
In the previous portion of this study we found a non-synonymous polymorphism within the S-gene. In this section we are trying to interpret its possible effect.
Outline
Obtain coding sequences of S proteins from a diverse group of coronaviruses. Generate amino acid alignment to assess conservation of the polymorphic location.
Input
Downloaded CDS sequences of coronavirus ...
Analysis of variation within individual COVID-19 samples | March 20 2020
What's the point?
The absolute majority of SARS-COV-2 data is in the form of assembled genomic sequences. This is unfortunate because any variation that exists within individual samples is obliterated--converted to the most frequent base--during the assembly process. However, knowing underlying evolutionary dynamics is critical for tracing evolution of the virus as it allows identification of genomic regions under different ...
